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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-2-18
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pubmed:abstractText |
Beyond the identification of 3-amino-5-hydroxybenzoic acid (AHBA) and D-glucosamine as biosynthetic precursors to mitomycin C (5) and FR900482 (6), little is known about the pathway Nature uses to prepare these antitumor antibiotics. To gain some insight into their biosynthesis, amino acids 1 and 2 as well as C-2 N-acetylated derivatives 3 and 4 were prepared. Preparation of these putative biosynthetic intermediates and N-acetylcysteamine thioester analogues 28 and 29 should enable confirmation of their involvement in FR900482 and mitomycin C biosynthesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-10094699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-10099135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-11033080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-11033083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-1184475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-11983332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-12105933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-15074934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-15074935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-17009278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-18047354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-3011250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-3192500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-3366695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-4810575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-9190287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-9364776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19161340-9383461
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1523-7052
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
791-4
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pubmed:dateRevised |
2011-4-25
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C.
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pubmed:affiliation |
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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