| pubmed-article:1916089 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1916089 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:1916089 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:1916089 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:1916089 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1916089 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1916089 | pubmed:dateCreated | 1991-11-15 | lld:pubmed |
| pubmed-article:1916089 | pubmed:abstractText | The lipid A domain of lipopolysaccharide (LPS) is a unique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of most gram-negative bacteria. Because of its profound pharmacological effects on animal cells, especially those of the immune system, lipid A is also known as endotoxin. Despite decades of earlier work, the precise chemistry of endotoxins and the biochemical pathways for their enzymatic synthesis have been elucidated only within the past 5 years. In this review, we summarize the essentials of endotoxin biochemistry and also present recent experiments aimed at identifying surface receptors, signal-transducing elements, transcriptional factors, and key intracellular targets involved in the response of animal cells to endotoxins. | lld:pubmed |
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| pubmed-article:1916089 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1916089 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1916089 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1916089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1916089 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1916089 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1916089 | pubmed:issn | 0892-6638 | lld:pubmed |
| pubmed-article:1916089 | pubmed:author | pubmed-author:DingAA | lld:pubmed |
| pubmed-article:1916089 | pubmed:author | pubmed-author:UlevitchR JRJ | lld:pubmed |
| pubmed-article:1916089 | pubmed:author | pubmed-author:RaetzC RCR | lld:pubmed |
| pubmed-article:1916089 | pubmed:author | pubmed-author:NathanC FCF | lld:pubmed |
| pubmed-article:1916089 | pubmed:author | pubmed-author:SibleyC HCH | lld:pubmed |
| pubmed-article:1916089 | pubmed:author | pubmed-author:WrightS DSD | lld:pubmed |
| pubmed-article:1916089 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1916089 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:1916089 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1916089 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1916089 | pubmed:pagination | 2652-60 | lld:pubmed |
| pubmed-article:1916089 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1916089 | pubmed:meshHeading | pubmed-meshheading:1916089-... | lld:pubmed |
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| pubmed-article:1916089 | pubmed:meshHeading | pubmed-meshheading:1916089-... | lld:pubmed |
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| pubmed-article:1916089 | pubmed:meshHeading | pubmed-meshheading:1916089-... | lld:pubmed |
| pubmed-article:1916089 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1916089 | pubmed:articleTitle | Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. | lld:pubmed |
| pubmed-article:1916089 | pubmed:affiliation | Department of Biochemistry, Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065. | lld:pubmed |
| pubmed-article:1916089 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1916089 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1916089 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:1916089 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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