rdf:type |
|
lifeskim:mentions |
umls-concept:C0018061,
umls-concept:C0030685,
umls-concept:C0032005,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205409,
umls-concept:C0391871,
umls-concept:C0392760,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1521761,
umls-concept:C1963578,
umls-concept:C2603343
|
pubmed:issue |
2
|
pubmed:dateCreated |
1977-5-27
|
pubmed:abstractText |
Isolated pituitary glands from adult male rats were maintained in a continuous flow system. Gn-RH (1000 pmol/ml) caused a characteristic release of cyclic AMP, LH, and FSH. Cyclic AMP (1000 nmol/ml) liberated a similar amount of both gonadotrophins. Theophylline (1 mmol/ml) enhanced the effect of cyclic AMP by 21% for LH and 41% for FSH. The infusion of oestradiol (184 pmol/ml) alone or before Gn-RH infusion did not produce a significant effect on the secretion of either gonadotrophin or cyclic AMP. In contrast, there was a significant reduction in the amount of LH (P less than 0-025) and FSH (P less than 0-05) released by pituitaries infused with oestradiol and cyclic AMP.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0022-4251
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
49
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
347-51
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:191605-Animals,
pubmed-meshheading:191605-Cyclic AMP,
pubmed-meshheading:191605-Estradiol,
pubmed-meshheading:191605-Follicle Stimulating Hormone,
pubmed-meshheading:191605-Gonadotropin-Releasing Hormone,
pubmed-meshheading:191605-Luteinizing Hormone,
pubmed-meshheading:191605-Male,
pubmed-meshheading:191605-Pituitary Gland,
pubmed-meshheading:191605-Pituitary Gland, Anterior,
pubmed-meshheading:191605-Rats,
pubmed-meshheading:191605-Theophylline
|
pubmed:year |
1977
|
pubmed:articleTitle |
Studies on factors affecting release of gonadotrophins during the superfusion of isolated rat pituitaries.
|
pubmed:publicationType |
Journal Article,
In Vitro
|