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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0025677,
umls-concept:C0032529,
umls-concept:C0039667,
umls-concept:C0080103,
umls-concept:C0185117,
umls-concept:C0600688,
umls-concept:C0871261,
umls-concept:C1332986,
umls-concept:C1420117,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-14
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pubmed:abstractText |
To determine the influence of the genotype and the level of expression of different enzymes involved in folate metabolism on the response to and toxicity of high-dose methotrexate treatment in pediatric osteosarcomas.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Folate Receptors, GPI-Anchored,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrofolate Dehydrogenase
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1097-6833
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
688-93
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19159907-Adolescent,
pubmed-meshheading:19159907-Antimetabolites, Antineoplastic,
pubmed-meshheading:19159907-Bone Neoplasms,
pubmed-meshheading:19159907-Carrier Proteins,
pubmed-meshheading:19159907-Case-Control Studies,
pubmed-meshheading:19159907-Dose-Response Relationship, Drug,
pubmed-meshheading:19159907-Drug Resistance, Neoplasm,
pubmed-meshheading:19159907-Female,
pubmed-meshheading:19159907-Folate Receptors, GPI-Anchored,
pubmed-meshheading:19159907-Folic Acid,
pubmed-meshheading:19159907-Gastrointestinal Diseases,
pubmed-meshheading:19159907-Genotype,
pubmed-meshheading:19159907-Hematologic Diseases,
pubmed-meshheading:19159907-Humans,
pubmed-meshheading:19159907-Kidney Diseases,
pubmed-meshheading:19159907-Male,
pubmed-meshheading:19159907-Methotrexate,
pubmed-meshheading:19159907-Osteosarcoma,
pubmed-meshheading:19159907-Polymerase Chain Reaction,
pubmed-meshheading:19159907-Polymorphism, Genetic,
pubmed-meshheading:19159907-RNA, Messenger,
pubmed-meshheading:19159907-Receptors, Cell Surface,
pubmed-meshheading:19159907-Tetrahydrofolate Dehydrogenase
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pubmed:year |
2009
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pubmed:articleTitle |
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression.
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pubmed:affiliation |
Laboratory of Pediatrics, University of Navarra/University Clinic, Pamplona, Spain. apatigar@unav.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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