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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-3-13
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pubmed:abstractText |
New methods are needed to eradicate or prevent Chlamydia trachomatis infections. Blockade of epithelial membrane protein 2 (EMP2) by genetic silencing or neutralizing polyclonal antibody reduced chlamydial infectivity in vitro. This study tests the prediction that recombinant anti-EMP2 diabody could reduce early chlamydial infection of the genital tract in vivo. In a murine infection model, pretreatment with anti-EMP2 diabody, as compared with control diabody, significantly reduced bacterial load, tissue production of inflammatory cytokines, recruitment of polymorphonuclear leukocytes, and local tissue inflammation. These findings support EMP2 as a potential preventative and therapeutic target for genital chlamydial infection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1574-695X
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pubmed:author |
pubmed-author:BraunJonathanJ,
pubmed-author:ChanAnn MAM,
pubmed-author:CoulamCatherine PCP,
pubmed-author:GordonLynn KLK,
pubmed-author:KellyKathleen AKA,
pubmed-author:LepinEric MEM,
pubmed-author:MareninovSergeyS,
pubmed-author:MonizRaymond JRJ,
pubmed-author:NagyAgnesA,
pubmed-author:ShimazakiKaoriK,
pubmed-author:WadehraMadhuriM,
pubmed-author:WuAnna MAM
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pubmed:issnType |
Electronic
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
240-9
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pubmed:dateRevised |
2011-1-7
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pubmed:meshHeading |
pubmed-meshheading:19159428-Animals,
pubmed-meshheading:19159428-Chlamydia Infections,
pubmed-meshheading:19159428-Chlamydia muridarum,
pubmed-meshheading:19159428-Colony Count, Microbial,
pubmed-meshheading:19159428-Cytokines,
pubmed-meshheading:19159428-Female,
pubmed-meshheading:19159428-Genital Diseases, Female,
pubmed-meshheading:19159428-Immunoglobulins,
pubmed-meshheading:19159428-Inflammation,
pubmed-meshheading:19159428-Membrane Glycoproteins,
pubmed-meshheading:19159428-Mice,
pubmed-meshheading:19159428-Mice, Inbred BALB C
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pubmed:year |
2009
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pubmed:articleTitle |
Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model.
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pubmed:affiliation |
Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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