Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-1-22
pubmed:abstractText
Prion protein (PrP)-like molecule, doppel (Dpl), is neurotoxic in mice, causing Purkinje cell degeneration. In contrast, PrP antagonizes Dpl in trans, rescuing mice from Purkinje cell death. We have previously shown that PrP with deletion of the N-terminal residues 23-88 failed to neutralize Dpl in mice, indicating that the N-terminal region, particularly that including residues 23-88, may have trans-protective activity against Dpl. Interestingly, PrP with deletion elongated to residues 121 or 134 in the N-terminal region was shown to be similarly neurotoxic to Dpl, indicating that the PrP C-terminal region may have toxicity which is normally prevented by the N-terminal domain in cis. We recently investigated further roles for the N-terminal region of PrP in antagonistic interactions with Dpl by producing three different types of transgenic mice. These mice expressed PrP with deletion of residues 25-50 or 51-90, or a fusion protein of the N-terminal region of PrP with Dpl. Here, we discuss a possible model for the antagonistic interaction between PrP and Dpl.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-10421360, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-10525406, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-10930132, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-11073804, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-11179214, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-11226243, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-11312611, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-11522774, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-11734625, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-12759361, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-14752167, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-14753456, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-15007176, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-15194501, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-15215178, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-15531106, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-15596141, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-15890950, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-16198494, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-1675487, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-17034959, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-17245436, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-17245437, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-17388948, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-18562311, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-18566584, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-2444340, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-2859120, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-7642585, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-7902575, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-8464494, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-8606772, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-9280298, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-9568713, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158506-9811807
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1933-690X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-11
pubmed:dateRevised
2011-9-20
pubmed:meshHeading
pubmed:articleTitle
Antagonistic roles of the N-terminal domain of prion protein to doppel.
pubmed:affiliation
Division of Molecular Neurobiology, The Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan. sakaguch@ier.tokushima-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't