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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-1-22
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pubmed:abstractText |
A case of L-type-like atypical bovine spongiform encephalopathy was detected in 14-year-old Japanese black beef cattle (BSE/JP24). To clarify the biological and biochemical properties of the prion in BSE/JP24, we performed a transmission study with wild-type mice and bovinized transgenic mice (TgBoPrP). The BSE/JP24 prion was transmitted to TgBoPrP mice with the incubation period of 199.7 +/- 3.4 days, which was shorter than that of classical BSE (C-BSE) (223.5 +/- 13.5 days). Further, C-BSE was transmitted to wild-type mice with the incubation period of about 409 days, whereas BSE/JP24 prion inoculated mice showed no clinical signs up to 649 days. Severe vacuolation and a widespread and uniform distribution of PrP(Sc) were pathologically observed in the brain of BSE/JP24 prion affected TgBoPrP mice. The molecular weight and glycoform ratio of PrP(Sc) in BSE/JP24 were different from those in C-BSE, and PrP(Sc) in BSE/JP24 exhibited weaker proteinase K resistance than that in C-BSE. These findings revealed that the BSE/JP24 prion has distinct biological and biochemical properties reported for that of C-BSE. Interestingly, a shorter incubation period was observed at the subsequent passage of the BSE/JP24 prion to TgBoPrP mice (152.2 +/- 3.1 days). This result implies that BSE/JP24 prion has newly emerged and showed the possibility that L-type BSE prion might be classified into multiple strains.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-10415165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-10623653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-11152682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-1347795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-14638998,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-14710195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-14970340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-15671162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-15707980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-16735593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-1675487,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19158500-9453128
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1933-690X
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pubmed:author |
pubmed-author:HagiwaraKen'ichiK,
pubmed-author:ImamuraMorikazuM,
pubmed-author:IwamaruYoshifumiY,
pubmed-author:MasujinKentaroK,
pubmed-author:MatsuuraYuichiY,
pubmed-author:MohriShirouS,
pubmed-author:OkadaHiroyukiH,
pubmed-author:SataTetsutaroT,
pubmed-author:ShuYujingY,
pubmed-author:YamakawaYoshioY,
pubmed-author:YokoyamaTakashiT
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-8
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pubmed:dateRevised |
2011-9-20
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pubmed:meshHeading |
pubmed-meshheading:19158500-Animals,
pubmed-meshheading:19158500-Blotting, Western,
pubmed-meshheading:19158500-Cattle,
pubmed-meshheading:19158500-Encephalopathy, Bovine Spongiform,
pubmed-meshheading:19158500-Endopeptidase K,
pubmed-meshheading:19158500-Glycoproteins,
pubmed-meshheading:19158500-Immunohistochemistry,
pubmed-meshheading:19158500-Mice,
pubmed-meshheading:19158500-Mice, Transgenic,
pubmed-meshheading:19158500-Molecular Weight,
pubmed-meshheading:19158500-Nervous System,
pubmed-meshheading:19158500-Positron-Emission Tomography,
pubmed-meshheading:19158500-PrPSc Proteins,
pubmed-meshheading:19158500-Protein Conformation,
pubmed-meshheading:19158500-Protein Stability
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pubmed:articleTitle |
Biological and biochemical characterization of L-type-like bovine spongiform encephalopathy (BSE) detected in Japanese black beef cattle.
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pubmed:affiliation |
Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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