| pubmed-article:19158283 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19158283 | lifeskim:mentions | umls-concept:C0343363 | lld:lifeskim |
| pubmed-article:19158283 | lifeskim:mentions | umls-concept:C0020017 | lld:lifeskim |
| pubmed-article:19158283 | lifeskim:mentions | umls-concept:C0868928 | lld:lifeskim |
| pubmed-article:19158283 | lifeskim:mentions | umls-concept:C0031525 | lld:lifeskim |
| pubmed-article:19158283 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:19158283 | lifeskim:mentions | umls-concept:C2713569 | lld:lifeskim |
| pubmed-article:19158283 | lifeskim:mentions | umls-concept:C1875307 | lld:lifeskim |
| pubmed-article:19158283 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19158283 | pubmed:dateCreated | 2009-3-4 | lld:pubmed |
| pubmed-article:19158283 | pubmed:abstractText | A pentavalent rotavirus vaccine for infants became available in the United States in February 2006. By 2007, vaccination rates nationwide were estimated to be approximately 50%. We studied the effectiveness of the vaccine in a real-world setting outside of a clinical trial. All children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for the presence of rotavirus antigen in the stool by enzyme-linked immunosorbent assay (ELISA [followed by genotyping if ELISA positive]) since the 1994-1995 epidemic season, presenting a unique opportunity to assess the impact of the recently introduced vaccine. The annual number of community-acquired cases over the preceding 13 years had approached or exceeded 100, with 271 cases in 2005 to 2006 and 167 cases in 2006 to 2007. In the 2007-2008 season, only 36 community-acquired cases were identified, representing an 87% reduction from the same period in 2005 to 2006. G3 was the predominant serotype, accounting for 15 community cases (42%). Our study is limited by its observational design using historical comparisons. Nonetheless, the abrupt decline in rotavirus gastroenteritis cases during the 2007-2008 season likely resulted from vaccination. Because protection rates appeared to have exceeded vaccination rates, herd immunity may have contributed to some degree to the effectiveness of the vaccine. | lld:pubmed |
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| pubmed-article:19158283 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19158283 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19158283 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19158283 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19158283 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19158283 | pubmed:issn | 1556-679X | lld:pubmed |
| pubmed-article:19158283 | pubmed:author | pubmed-author:HodinkaRichar... | lld:pubmed |
| pubmed-article:19158283 | pubmed:author | pubmed-author:DiNubileMark... | lld:pubmed |
| pubmed-article:19158283 | pubmed:author | pubmed-author:ClarkH FredHF | lld:pubmed |
| pubmed-article:19158283 | pubmed:author | pubmed-author:LawleyDianeD | lld:pubmed |
| pubmed-article:19158283 | pubmed:author | pubmed-author:MalletteLaura... | lld:pubmed |
| pubmed-article:19158283 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19158283 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:19158283 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19158283 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19158283 | pubmed:pagination | 382-6 | lld:pubmed |
| pubmed-article:19158283 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19158283 | pubmed:meshHeading | pubmed-meshheading:19158283... | lld:pubmed |
| pubmed-article:19158283 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19158283 | pubmed:articleTitle | Decline in cases of rotavirus gastroenteritis presenting to The Children's Hospital of Philadelphia after introduction of a pentavalent rotavirus vaccine. | lld:pubmed |
| pubmed-article:19158283 | pubmed:affiliation | Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. clarkf@email.chop.edu | lld:pubmed |
| pubmed-article:19158283 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19158283 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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