Linked Life Data

19158283

Source:http://linkedlifedata.com/resource/pubmed/id/19158283

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-3-4
pubmed:abstractText
A pentavalent rotavirus vaccine for infants became available in the United States in February 2006. By 2007, vaccination rates nationwide were estimated to be approximately 50%. We studied the effectiveness of the vaccine in a real-world setting outside of a clinical trial. All children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for the presence of rotavirus antigen in the stool by enzyme-linked immunosorbent assay (ELISA [followed by genotyping if ELISA positive]) since the 1994-1995 epidemic season, presenting a unique opportunity to assess the impact of the recently introduced vaccine. The annual number of community-acquired cases over the preceding 13 years had approached or exceeded 100, with 271 cases in 2005 to 2006 and 167 cases in 2006 to 2007. In the 2007-2008 season, only 36 community-acquired cases were identified, representing an 87% reduction from the same period in 2005 to 2006. G3 was the predominant serotype, accounting for 15 community cases (42%). Our study is limited by its observational design using historical comparisons. Nonetheless, the abrupt decline in rotavirus gastroenteritis cases during the 2007-2008 season likely resulted from vaccination. Because protection rates appeared to have exceeded vaccination rates, herd immunity may have contributed to some degree to the effectiveness of the vaccine.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-12737740, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-15070985, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-16333070, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-16394298, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-16394299, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-16410759, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-16804425, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-17403845, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-18418345, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-18583958, http://linkedlifedata.com/resource/pubmed/commentcorrection/19158283-18595974
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1556-679X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
382-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Decline in cases of rotavirus gastroenteritis presenting to The Children's Hospital of Philadelphia after introduction of a pentavalent rotavirus vaccine.
pubmed:affiliation
Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. clarkf@email.chop.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't