Source:http://linkedlifedata.com/resource/pubmed/id/19157826
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-11-30
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| pubmed:abstractText |
It has been hypothesized that oxidative stress plays a key role in aging. In order to elucidate the role of the antioxidant network - including alpha-tocopherol (alphaT) and alphaT transfer protein - in aging in vivo, alpha-tocopherol transfer protein knockout (alphaTTP(-/-)) mice were fed a vitamin-E-depleted diet, and wild-type (WT) mice were fed a diet containing 0.002 wt.% alphaT from the age of 3 months to 1 1/2 years. The lipid oxidation markers total hydroxyoctadecadienoic acid (tHODE) and 8-iso-prostaglandin F(2)alpha, and antioxidant levels in the blood, liver and brain were measured at 3, 6, 12 and 18 months. tHODE levels in the plasma of alphaTTP(-/-) mice were elevated at 6 months compared to 3 months, and were significantly higher those in WT mice, although they decreased thereafter. On the other hand, tHODE levels in the liver and brain were constantly higher in alphaTTP(-/-) mice than in WT mice. Motor activities decreased with aging in both mouse types; however, those in the alphaTTP(-/-) mice were lower than those in the WT mice. It is intriguing to note that motor activities were significantly correlated with the stereoisomer ratio (Z,E/E,E) of HODE, which is a measure of antioxidant capacity in vivo, in the plasma, in the liver and even in the brain, but not with other factors such as antioxidant levels. In summary, using the biomarker tHODE and its stereoisomer ratio, we demonstrated that alphaT depletion was associated with a decrease in motor function, and that this may be primarily attributable to a decrease in the total antioxidant capacity in vivo.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-epi-prostaglandin F2alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbituric Acid Reactive...,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquinone,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Tocopherol,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-tocopherol transfer protein,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxyoctadecadienoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/ubiquinone 9
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1873-4847
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
21
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
66-76
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| pubmed:meshHeading |
pubmed-meshheading:19157826-Aging,
pubmed-meshheading:19157826-Animals,
pubmed-meshheading:19157826-Ascorbic Acid,
pubmed-meshheading:19157826-Biological Markers,
pubmed-meshheading:19157826-Brain Chemistry,
pubmed-meshheading:19157826-Carrier Proteins,
pubmed-meshheading:19157826-Dinoprost,
pubmed-meshheading:19157826-Fatty Acids, Unsaturated,
pubmed-meshheading:19157826-Female,
pubmed-meshheading:19157826-Lipid Peroxidation,
pubmed-meshheading:19157826-Male,
pubmed-meshheading:19157826-Mice,
pubmed-meshheading:19157826-Mice, Inbred C57BL,
pubmed-meshheading:19157826-Mice, Knockout,
pubmed-meshheading:19157826-Motor Activity,
pubmed-meshheading:19157826-Oxidative Stress,
pubmed-meshheading:19157826-Specific Pathogen-Free Organisms,
pubmed-meshheading:19157826-Stereoisomerism,
pubmed-meshheading:19157826-Thiobarbituric Acid Reactive Substances,
pubmed-meshheading:19157826-Ubiquinone,
pubmed-meshheading:19157826-Vitamin E Deficiency,
pubmed-meshheading:19157826-alpha-Tocopherol
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| pubmed:year |
2010
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| pubmed:articleTitle |
The role of alpha-tocopherol in motor hypofunction with aging in alpha-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers.
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| pubmed:affiliation |
Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563-8577, Japan. yoshida-ya@aist.go.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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