| pubmed-article:19157572 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19157572 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:19157572 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:19157572 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:19157572 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:19157572 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:19157572 | pubmed:dateCreated | 2009-2-23 | lld:pubmed |
| pubmed-article:19157572 | pubmed:abstractText | This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. | lld:pubmed |
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| pubmed-article:19157572 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19157572 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19157572 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19157572 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19157572 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19157572 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:ChauhanAbhaA | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:SheikhAshfaq... | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:LiXiu-MinXM | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:LiXiaohongX | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:JiLinaL | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:ChauhanVedV | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:MalikMazharM | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:BrownTedT | lld:pubmed |
| pubmed-article:19157572 | pubmed:author | pubmed-author:PatilSangitaS | lld:pubmed |
| pubmed-article:19157572 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19157572 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19157572 | pubmed:volume | 207 | lld:pubmed |
| pubmed-article:19157572 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19157572 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19157572 | pubmed:pagination | 111-6 | lld:pubmed |
| pubmed-article:19157572 | pubmed:dateRevised | 2010-9-23 | lld:pubmed |
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| pubmed-article:19157572 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19157572 | pubmed:articleTitle | Elevated immune response in the brain of autistic patients. | lld:pubmed |
| pubmed-article:19157572 | pubmed:affiliation | Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, USA. xiaohong.li@mssm.edu | lld:pubmed |
| pubmed-article:19157572 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19157572 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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