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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2009-2-23
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pubmed:abstractText |
This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-11244051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-11357950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-11694332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-11694696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-11733747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-11754998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-11803234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-12378124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-12740674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-15546155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-15764907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-15944202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-16029895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-16139734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-16360218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-16494951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-16627934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-2540776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-7880387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-8893001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-8964908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-9403369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19157572-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
207
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-6
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pubmed:dateRevised |
2010-9-23
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pubmed:meshHeading |
pubmed-meshheading:19157572-Adolescent,
pubmed-meshheading:19157572-Adult,
pubmed-meshheading:19157572-Autistic Disorder,
pubmed-meshheading:19157572-Brain,
pubmed-meshheading:19157572-Case-Control Studies,
pubmed-meshheading:19157572-Chemokines,
pubmed-meshheading:19157572-Child,
pubmed-meshheading:19157572-Child, Preschool,
pubmed-meshheading:19157572-Cytokines,
pubmed-meshheading:19157572-Female,
pubmed-meshheading:19157572-Humans,
pubmed-meshheading:19157572-Male,
pubmed-meshheading:19157572-Statistics, Nonparametric,
pubmed-meshheading:19157572-Th1 Cells,
pubmed-meshheading:19157572-Th2 Cells,
pubmed-meshheading:19157572-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Elevated immune response in the brain of autistic patients.
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pubmed:affiliation |
Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, USA. xiaohong.li@mssm.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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