rdf:type |
|
lifeskim:mentions |
umls-concept:C0009013,
umls-concept:C0023473,
umls-concept:C0030705,
umls-concept:C0033213,
umls-concept:C0332325,
umls-concept:C0439064,
umls-concept:C0596988,
umls-concept:C0935989,
umls-concept:C1268567,
umls-concept:C1519252,
umls-concept:C1527148,
umls-concept:C1705294,
umls-concept:C2757011
|
pubmed:issue |
1
|
pubmed:dateCreated |
2009-5-1
|
pubmed:abstractText |
With the increasing use of new tyrosine kinase inhibitors it has been suggested that the spectrum of kinase domain mutations may change and possible selection of new resistant clones may occur. We describe a Ph + chronic myeloid leukaemia (CML) patient with primary resistance to imatinib who received without success sequential therapy with multiple TKIs, and developed sequential emergence of kinase domain mutations after these treatments.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1432-0843
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
64
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
195-7
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:19156415-Antineoplastic Agents,
pubmed-meshheading:19156415-Drug Resistance, Neoplasm,
pubmed-meshheading:19156415-Female,
pubmed-meshheading:19156415-Humans,
pubmed-meshheading:19156415-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:19156415-Middle Aged,
pubmed-meshheading:19156415-Mutation,
pubmed-meshheading:19156415-Piperazines,
pubmed-meshheading:19156415-Protein Kinase Inhibitors,
pubmed-meshheading:19156415-Protein-Tyrosine Kinases,
pubmed-meshheading:19156415-Pyrimidines
|
pubmed:year |
2009
|
pubmed:articleTitle |
Sequential development of mutant clones in an imatinib resistant chronic myeloid leukaemia patient following sequential treatment with multiple tyrosine kinase inhibitors: an emerging problem?
|
pubmed:affiliation |
Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy. breccia@bce.uniroma1.it
|
pubmed:publicationType |
Journal Article,
Case Reports
|