Linked Life Data

19155102

Source:http://linkedlifedata.com/resource/pubmed/id/19155102

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-10-22
pubmed:abstractText
Hepatic lipase, also known as hepatic triglyceride lipase (LIPC), much like the major genetic risk factor for Alzheimer's disease (AD), apolipoprotein E (APOE), is associated with altered lipid metabolism. As such this link makes LIPC a potential functional candidate for AD risk. Previously, three single nucleotide polymorphisms (SNPs) have been investigated in AD with a lack of association reported. To rule out a possible contribution of other variants in LIPC, located at 15q21-q23, we used a detailed fine mapping approach in a German case-control sample. Genotyping of 25 single nucleotide polymorphisms covering the complete LIPC gene and haplotypic analysis revealed no association with AD. Thus, we conclude that LIPC can be excluded as a major functional candidate gene conferring risk to AD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1558-1497
pubmed:author
pubmed:copyrightInfo
Copyright © 2008 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2192-3
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
No association of lipase C polymorphisms with Alzheimer's disease.
pubmed:affiliation
Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU-München, Munich, Germany. simon.laws@lrz.tu-muenchen.de
pubmed:publicationType
Journal Article