Linked Life Data

19153519

Source:http://linkedlifedata.com/resource/pubmed/id/19153519

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-1-20
pubmed:abstractText
BACKGROUND: The task of diagnosing growth hormone deficiency (GHD) in adults is cumbersome because of the paucity of biological endpoints. Consequently, over the past decade different organizations have attempted to develop homogeneous criteria and methodology for worldwide use. GHD should be biochemically confirmed within an appropriate clinical context - but only if there is the intention to treat. Clinically, patients investigated for GHD should include those with signs and symptoms or a past history of hypothalamo-pituitary dysfunction and those with a history of cranial irradiation, tumour treatment, traumatic brain injury or subarachnoid haemorrhage. CONCLUSIONS: Subjects with >/=3 pituitary hormone deficiencies plus a low insulin-like growth factor I level do not need provocative testing. For those who must be tested, arguably the most commonly used provocative tests are the insulin tolerance test and the glucagon, GH-releasing hormone (GHRH) + arginine and GHRH + GH-releasing hexapeptide tests. Cutoffs differ across tests and results may be influenced by gender, age, body mass index and the assay reference preparation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1423-0046
pubmed:author
pubmed:copyrightInfo
Copyright 2009 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
71 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
New guidelines for the diagnosis of growth hormone deficiency in adults.
pubmed:affiliation
Department of Medicine, Complejo Hospitalario Universitario de Santiago, CIBER de Fisiopatología Obesidad y Nutrición, Instituto Salud Carlos III, Santiago de Compostela, Spain. meffcasa@usc.es
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Practice Guideline