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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-3-11
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pubmed:abstractText |
Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8(+) T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC, compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-11014195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-12552014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-12768008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-14770175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-15067030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-15944251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-16369537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-16501126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-16537629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-16641269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-16641299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-16682496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-17151109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-17173051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-17182686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-17251286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-17616974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-17728232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-18275276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-18562530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-18580606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-18596105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-18945771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-18971283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-8139022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-8597949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-9018241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-9050875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-9359718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19153230-9933172
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1098-5514
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pubmed:author |
pubmed-author:BlockBrian LBL,
pubmed-author:BrockmanMark AMA,
pubmed-author:BrummeChanson JCJ,
pubmed-author:BrummeZabrina LZL,
pubmed-author:HarriganP RichardPR,
pubmed-author:JohnMinaM,
pubmed-author:MallalSimonS,
pubmed-author:MiuraToshiyukiT,
pubmed-author:PereyraFlorenciaF,
pubmed-author:TrochaAlicjaA,
pubmed-author:WalkerBruce DBD
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pubmed:issnType |
Electronic
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3407-12
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pubmed:dateRevised |
2010-1-12
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pubmed:meshHeading |
pubmed-meshheading:19153230-Epitopes, T-Lymphocyte,
pubmed-meshheading:19153230-HIV Infections,
pubmed-meshheading:19153230-HIV Long-Term Survivors,
pubmed-meshheading:19153230-HIV-1,
pubmed-meshheading:19153230-Humans,
pubmed-meshheading:19153230-Mutation, Missense,
pubmed-meshheading:19153230-Plasma,
pubmed-meshheading:19153230-Polymorphism, Genetic,
pubmed-meshheading:19153230-Selection, Genetic,
pubmed-meshheading:19153230-Viral Load,
pubmed-meshheading:19153230-Viremia,
pubmed-meshheading:19153230-gag Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:19153230-nef Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:19153230-pol Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2009
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pubmed:articleTitle |
HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers.
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pubmed:affiliation |
Ragon Institute (formerly Partners AIDS Research Center), Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. miura523@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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