Linked Life Data

19151626

Source:http://linkedlifedata.com/resource/pubmed/id/19151626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-5
pubmed:abstractText
CD200 is a membrane glycoprotein that suppresses immune activity via its receptor, CD200R. CD200-CD200R interactions have recently been considered to contribute to the "immune privileged" status of the central nervous system (CNS). The mechanisms by which these interactions take place are not well understood in part because there is limited detailed information on the distribution of CD200 and CD200R in the CNS. Here, we used immunohistochemistry to characterize the distinct anatomical and cellular distribution of these molecules in multiple sclerosis (MS) lesions and controls. CD200 was robustly expressed in gray matter areas including the cerebral cortex, hippocampus, striatum, cerebellum, and spinal cord, where neurons appeared immunopositive. CD200 expression was also detected in oligodendrocytes, but not in astrocytes or microglia. In CNS samples from MS patients, CD200 expression was additionally observed on reactive astrocytes in chronic active plaque centers, despite our previous finding of an overall decrease ofCD200 expression in MS lesions. In contrast to CD200, the immunolocalization pattern of CD200R was very distinct, showing high expression on perivascular macrophages in both gray and white matter. Using flow cytometry, we also found that human primary microglia express low levels of CD200R. These data suggest that CD200-mediated immune suppression may occur not only via neuron-microglia interactions, but also via glia-glia interactions, especially in inflammatory conditions in which an immune-suppressive environment needs to be restored; this may occur as a result of increased CD200 expression on reactive astrocytes.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-67
pubmed:dateRevised
2009-8-27
pubmed:meshHeading
pubmed-meshheading:19151626-Adult, pubmed-meshheading:19151626-Aged, pubmed-meshheading:19151626-Aged, 80 and over, pubmed-meshheading:19151626-Animals, pubmed-meshheading:19151626-Antigens, CD, pubmed-meshheading:19151626-Antigens, Surface, pubmed-meshheading:19151626-Astrocytes, pubmed-meshheading:19151626-Biological Markers, pubmed-meshheading:19151626-Brain, pubmed-meshheading:19151626-Cell Communication, pubmed-meshheading:19151626-Central Nervous System, pubmed-meshheading:19151626-Female, pubmed-meshheading:19151626-Gliosis, pubmed-meshheading:19151626-Humans, pubmed-meshheading:19151626-Immunohistochemistry, pubmed-meshheading:19151626-Male, pubmed-meshheading:19151626-Mice, pubmed-meshheading:19151626-Microglia, pubmed-meshheading:19151626-Middle Aged, pubmed-meshheading:19151626-Multiple Sclerosis, pubmed-meshheading:19151626-Neuroglia, pubmed-meshheading:19151626-Neurons, pubmed-meshheading:19151626-Receptors, Cell Surface, pubmed-meshheading:19151626-Spinal Cord
pubmed:year
2009
pubmed:articleTitle
Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions.
pubmed:affiliation
Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. nathalie.koning@vumc.nl [corrected]
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't