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rdf:type |
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lifeskim:mentions |
umls-concept:C0007131,
umls-concept:C0017262,
umls-concept:C0042172,
umls-concept:C0185117,
umls-concept:C0332281,
umls-concept:C0684249,
umls-concept:C0871261,
umls-concept:C1122962,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
4
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|
pubmed:dateCreated |
2009-3-26
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pubmed:abstractText |
Epidermal growth factor receptor (EGFR) inhibitors are effective in a subset of patients with non-small-cell lung cancer (NSCLC). We previously showed that E-cadherin expression associates with gefitinib activity. Here, we correlated the expressions of ErbB-3 and E-cadherin in NSCLC tumors and cell lines, their effect on response to gefitinib, and induction of both by the histone deacetylase (HDAC) inhibitors vorinostat and SNDX-275.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-10383446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-10400677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-10797281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-11864595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-11902574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-12057867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-12937339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-14570950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-15731348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-15897550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-15955865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16014882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16014883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16230409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16288303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16357156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16361555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16424029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16707605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-16857813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-17075123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-17179232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-17299729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-17383217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-17541031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-17875771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-18579665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19150934-7515147
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1569-8041
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
689-95
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pubmed:dateRevised |
2010-9-23
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pubmed:meshHeading |
pubmed-meshheading:19150934-Antineoplastic Agents,
pubmed-meshheading:19150934-Base Sequence,
pubmed-meshheading:19150934-Blotting, Western,
pubmed-meshheading:19150934-Cadherins,
pubmed-meshheading:19150934-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:19150934-Cohort Studies,
pubmed-meshheading:19150934-DNA Primers,
pubmed-meshheading:19150934-Enzyme Inhibitors,
pubmed-meshheading:19150934-Female,
pubmed-meshheading:19150934-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19150934-Histone Deacetylase Inhibitors,
pubmed-meshheading:19150934-Humans,
pubmed-meshheading:19150934-Immunoprecipitation,
pubmed-meshheading:19150934-Lung Neoplasms,
pubmed-meshheading:19150934-Male,
pubmed-meshheading:19150934-Middle Aged,
pubmed-meshheading:19150934-Quinazolines,
pubmed-meshheading:19150934-Receptor, erbB-3
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pubmed:year |
2009
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pubmed:articleTitle |
ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC).
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pubmed:affiliation |
Department of Medicine-Division of Medical Oncology, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, CO 80010, USA. samir.witta@uchsc.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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