Linked Life Data

19149498

Source:http://linkedlifedata.com/resource/pubmed/id/19149498

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-19
pubmed:abstractText
The exact biological functions of the aminoacyl-histidine dipeptides in ophthalmology are still unknown but they are the subject of intensive research activities at Innovative Vision Products, Inc. (IVP). Numerous studies have demonstrated, both at the tissue and organelle levels, that naturally occuring imidazole containing peptidomimetics possess strong and specific antioxidant properties, by preventing and reducing the accumulation of oxidised products derived from the lipid peroxidation (LPO) of biological membranes. Carnosine has been shown to act as a competitive inhibitor of the non-enzymatic glycosylation of proteins.Thus, carnosine may prevent and reverse (de-link) the formation of the advanced glycation end-products (AGEs), whose accumulation in the ocular tissues has been proposed to play a direct role in the etiology and pathogenesis of cataract and diabetic ocular complications (DOC). Besides, histidine-containing dipeptides are believed to act as cytosolic buffering agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1574-8847
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4-37
pubmed:meshHeading
pubmed-meshheading:19149498-Administration, Topical, pubmed-meshheading:19149498-Aged, pubmed-meshheading:19149498-Aged, 80 and over, pubmed-meshheading:19149498-Antioxidants, pubmed-meshheading:19149498-Carnosine, pubmed-meshheading:19149498-Cataract, pubmed-meshheading:19149498-Contact Lenses, pubmed-meshheading:19149498-Double-Blind Method, pubmed-meshheading:19149498-Drug Delivery Systems, pubmed-meshheading:19149498-Female, pubmed-meshheading:19149498-Glycosylation, pubmed-meshheading:19149498-Glycosylation End Products, Advanced, pubmed-meshheading:19149498-Histidine, pubmed-meshheading:19149498-Humans, pubmed-meshheading:19149498-Hydrazines, pubmed-meshheading:19149498-Lipid Peroxidation, pubmed-meshheading:19149498-Liposomes, pubmed-meshheading:19149498-Lubricants, pubmed-meshheading:19149498-Male, pubmed-meshheading:19149498-Middle Aged, pubmed-meshheading:19149498-Ophthalmic Solutions, pubmed-meshheading:19149498-Oxidative Stress, pubmed-meshheading:19149498-Prodrugs, pubmed-meshheading:19149498-Visual Acuity
pubmed:year
2009
pubmed:articleTitle
State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
pubmed:affiliation
Innovative Vision Products, Inc., County of New Castle, Delaware 19810, USA. markbabizhayev@mail.ru
pubmed:publicationType
Journal Article, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't