Source:http://linkedlifedata.com/resource/pubmed/id/19148150
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
2009-1-16
|
pubmed:abstractText |
Cherney and co-workers examine the functional phenotype of the G894T eNOS polymorphism in a selected group of apparently healthy subjects. The investigators used L-arginine infusion and induced changes in renal hemodynamics. While L-arginine increased effective plasma flow and glomerular filtration rate in GG subjects, these responses were blunted in GT/TT subjects, suggesting that either the G894T polymorphism impairs eNOS function, or GG subjects exhibit augmented eNOS responsiveness to L-arginine. The complexity of this seemingly straightforward conclusion deserves elaboration.
|
pubmed:commentsCorrections | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1523-1755
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:volume |
75
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
255-7
|
pubmed:meshHeading |
pubmed-meshheading:19148150-Amino Acid Substitution,
pubmed-meshheading:19148150-Arginine,
pubmed-meshheading:19148150-Aspartic Acid,
pubmed-meshheading:19148150-Binding Sites,
pubmed-meshheading:19148150-Glomerular Filtration Rate,
pubmed-meshheading:19148150-Humans,
pubmed-meshheading:19148150-Nitric Oxide,
pubmed-meshheading:19148150-Nitric Oxide Synthase Type III,
pubmed-meshheading:19148150-Polymorphism, Genetic,
pubmed-meshheading:19148150-Protein Binding,
pubmed-meshheading:19148150-Renal Circulation,
pubmed-meshheading:19148150-Structure-Activity Relationship
|
pubmed:year |
2009
|
pubmed:articleTitle |
Endothelial nitric oxide synthase: from structure to function in one aspartic substitution.
|
pubmed:affiliation |
Department of Medicine, Renal Research Institute, New York Medical College, Valhalla, New York 10595, USA. michael_goligorsky@nymc.edu
|
pubmed:publicationType |
Journal Article,
Comment
|