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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-2-16
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pubmed:abstractText |
Versatile intermediates 12'-iodovinblastine, 12'-iodovincristine and 11'-iodovinorelbine were utilized as substrates for transition metal based chemistry which led to the preparation of novel analogues of the vinca alkaloids. The synthesis of key iodo intermediates, their transformation into final products, and the SAR based upon HeLa and MCF-7 cell toxicity assays is presented. Selected analogues 27 and 36 show promising anticancer activity in the P388 murine leukemia model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BuddeCherylC,
pubmed-author:ChenXinchaoX,
pubmed-author:FrankAnthony JAJ,
pubmed-author:FriedrichThomasT,
pubmed-author:JohnsonRandallR,
pubmed-author:LeyhaneAndrew JAJ,
pubmed-author:ManningDavid DDD,
pubmed-author:PeaceDeniseD,
pubmed-author:RAOT TTT,
pubmed-author:RalphJeffery MJM,
pubmed-author:ScottIan LIL,
pubmed-author:StevensJason MJM,
pubmed-author:SurmanMatthew DMD,
pubmed-author:VossMatthew EME,
pubmed-author:WolfMarkM,
pubmed-author:XieDejianD
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1245-9
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pubmed:meshHeading |
pubmed-meshheading:19147348-Animals,
pubmed-meshheading:19147348-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:19147348-Disease Models, Animal,
pubmed-meshheading:19147348-Drug Screening Assays, Antitumor,
pubmed-meshheading:19147348-HeLa Cells,
pubmed-meshheading:19147348-Humans,
pubmed-meshheading:19147348-Leukemia P388,
pubmed-meshheading:19147348-Mice,
pubmed-meshheading:19147348-Molecular Structure,
pubmed-meshheading:19147348-Structure-Activity Relationship,
pubmed-meshheading:19147348-Vinblastine,
pubmed-meshheading:19147348-Vinca Alkaloids,
pubmed-meshheading:19147348-Vincristine
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis and SAR of vinca alkaloid analogues.
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pubmed:affiliation |
Albany Molecular Research, Inc., 26 Corporate Circle, PO Box 15098, Albany, NY 12212-5098, USA. matthew.voss@amriglobal.com
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pubmed:publicationType |
Journal Article
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