Source:http://linkedlifedata.com/resource/pubmed/id/19145298
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2009-1-15
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pubmed:abstractText |
We studied the capacity of anomeric pairs of alpha- and beta-dodecyl, alpha- and beta-(1-pentylhexyl), and alpha- and beta-cyclododecyl glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide) to stimulate the nonspecific resistance of mice to intraperitoneal infection of Staphylococcus aureus and Escherichia coli cultures. Intraperitoneal pretreatment with the test substances in a wide dose range increased survival of infected animals. No differences were found between the biological effects of alpha- and beta-dodecyl and alpha- and beta-(1-pentylhexyl) glycosides of muramyl dipeptide. An inverse relationship was found between stimulatory activity and dose of alpha- and beta-cyclododecyl glycosides of muramyl dipeptide during sepsis caused by Staphylococcus aureus.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-4888
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
623-5
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pubmed:meshHeading |
pubmed-meshheading:19145298-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:19145298-Adjuvants, Immunologic,
pubmed-meshheading:19145298-Animals,
pubmed-meshheading:19145298-Dose-Response Relationship, Drug,
pubmed-meshheading:19145298-Escherichia coli Infections,
pubmed-meshheading:19145298-Glycosides,
pubmed-meshheading:19145298-Mice,
pubmed-meshheading:19145298-Molecular Structure,
pubmed-meshheading:19145298-Sepsis,
pubmed-meshheading:19145298-Staphylococcal Infections,
pubmed-meshheading:19145298-Structure-Activity Relationship
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pubmed:year |
2008
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pubmed:articleTitle |
Biological activity of anomeric pairs of lipophilic glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine.
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pubmed:affiliation |
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. kalyuzhin@list.ru
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pubmed:publicationType |
Journal Article
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