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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-1-28
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pubmed:abstractText |
The differentiation of T cells along different lineages is central to the control of immunity. Here we have used a conditional gene knockout system to delete PKC lambda/iota selectively in activated T cells. With this system we have demonstrated that PKC lambda/iota is necessary for T-helper cell (Th2) cytokine production and optimal T-cell proliferation and allergic airway inflammation in vivo. Our data demonstrate that the activation of the transcription factors nuclear factor of activated T cells and NF-kappaB is impaired in PKC lambda/iota-deficient activated T cells. In addition, we present genetic knockout evidence in ex vivo experiments with primary T cells that PKC lambda/iota is critical for the control of cell polarity during T-cell activation. Therefore PKC lambda/iota emerges as a critical regulator of Th 2 activation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-11983158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-12569150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-15137944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-15475959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-15987782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-16337454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-16618596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-16874300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-16949360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-17053799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-17098202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-17332376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-17418783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-17641777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-17663978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-17981131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-18209061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-18329370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-18354157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-18400187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-18400188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144923-7904900
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1099-104
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19144923-Animals,
pubmed-meshheading:19144923-Cell Differentiation,
pubmed-meshheading:19144923-Cell Polarity,
pubmed-meshheading:19144923-Cell Proliferation,
pubmed-meshheading:19144923-Cytokines,
pubmed-meshheading:19144923-Hypersensitivity,
pubmed-meshheading:19144923-Immunoglobulin E,
pubmed-meshheading:19144923-Inflammation,
pubmed-meshheading:19144923-Isoenzymes,
pubmed-meshheading:19144923-Lymphocyte Activation,
pubmed-meshheading:19144923-Mice,
pubmed-meshheading:19144923-Mice, Knockout,
pubmed-meshheading:19144923-Ovalbumin,
pubmed-meshheading:19144923-Protein Kinase C,
pubmed-meshheading:19144923-Respiratory System,
pubmed-meshheading:19144923-Th2 Cells,
pubmed-meshheading:19144923-Transcription Factors,
pubmed-meshheading:19144923-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo.
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pubmed:affiliation |
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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