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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1991-11-13
|
| pubmed:abstractText |
There is a marked decrease of the right ventricular ejection fraction after the administration of a bolus of endotoxin to sheep. This hemodynamic response may be the result of thromboxane-mediated pulmonary hypertension. Right ventricular function was studied in an ovine model after the administration of endotoxin (1 microgram/kg Escherichia coli) with and without pretreatment with OKY-046, a selective thromboxane synthetase inhibitor.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0090-3493
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1294-302
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1914487-Animals,
pubmed-meshheading:1914487-Endotoxins,
pubmed-meshheading:1914487-Escherichia coli,
pubmed-meshheading:1914487-Heart Failure,
pubmed-meshheading:1914487-Hemodynamics,
pubmed-meshheading:1914487-Methacrylates,
pubmed-meshheading:1914487-Oxygen Consumption,
pubmed-meshheading:1914487-Sheep,
pubmed-meshheading:1914487-Thromboxane-A Synthase
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Inhibition of thromboxane synthesis reduces endotoxin-induced right ventricular failure in sheep.
|
| pubmed:affiliation |
Department of Anesthesiology, University of Texas Medical Branch, Galveston.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|