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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-1-15
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pubmed:abstractText |
The region on chromosome 6p21 (IDDM1) confers the largest part of genetic susceptibility to type 1 diabetes (T1D) with particular human leucocyte antigen (HLA) alleles predisposing and others protecting from it. As T1D is primarily a "sporadic" disease, the pathophysiology must involve gene-environment interactions. We searched for indirect evidence for such major histocompatibility complex (MHC)-environment interactions by asking two questions: (i) can the degree of an HLA association vary over time periods? and (ii) if a prenatal event like an intrauterine infection - that might cluster in seasons - leads to differences of HLA associations in patients with particular birth months?
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-11085185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-11453529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-11955561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-12012228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-12014524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-12116171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-12880128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-15530607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-15530631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-15984382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-16186404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-17130525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-17535862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-17607662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-17610416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-17631647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-17992179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-18004301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-18063992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-18252895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-18292986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-18478964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19143820-18776151
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1463-1326
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
88-91
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19143820-Antigens, CD,
pubmed-meshheading:19143820-CTLA-4 Antigen,
pubmed-meshheading:19143820-Diabetes Mellitus, Type 1,
pubmed-meshheading:19143820-Feasibility Studies,
pubmed-meshheading:19143820-Genetic Predisposition to Disease,
pubmed-meshheading:19143820-Genotype,
pubmed-meshheading:19143820-HLA-DQ Antigens,
pubmed-meshheading:19143820-HLA-DR Antigens,
pubmed-meshheading:19143820-Heterozygote,
pubmed-meshheading:19143820-Humans,
pubmed-meshheading:19143820-Seasons,
pubmed-meshheading:19143820-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth.
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pubmed:affiliation |
Department of Medicine, Division of Endocrinology, University Hospital Frankfurt, Frankfurt am Main, Germany. badenhoop@em.uni-frankfurt.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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