Source:http://linkedlifedata.com/resource/pubmed/id/19143752
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2009-1-20
|
pubmed:abstractText |
This study compared topical pimecrolimus with betamethasone in the treatment of pruritus and chronic skin lesions due to sulfur mustard exposure. Seventy male chemical-injured war veterans participated in this investigator-blinded clinical trial. They were randomized to receive pimecrolimus cream 1% (n = 35) or betamethasone cream 0.1% (n = 35) two times a day for 6 weeks. Dermatological examination and assessment of pruritus severity by a pruritic score questionnaire and visual analogue scale were done before and after the treatment course. A significant decrease (P < 0.05) in pruritus, burning sensation, and skin dryness was shown in both groups after the treatment. However, the severity of hyper- and hypopigmentation, vesicle, erythema, fissure, lichenification and excoriation did not decrease significantly in either group (P > 0.05). Mean (+/- standard deviation) pruritic scores at baseline for the pimecrolimus and betamethasone groups were 30.4 (+/- 8.0) and 33.6 (+/- 7.2), respectively (P = 0.103). These scores decreased to 18.8 (+/- 4.8) in the pimecrolimus and 20.8 (+/- 4.0) in the betamethasone groups after treatment; both showed a statistically significant decrease (P < 0.001). Change of pruritus score from baseline to after the treatment course was not statistically different between the two groups (P = 0.502). No serious side-effects were reported during the course of the treatment. Topical pimecrolimus 1% was as effective as betamethasone cream 0.1% in controlling pruritus, burning sensation and skin dryness of sulfur mustard-exposed patients.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Betamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Chemical Warfare Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Mustard Gas,
http://linkedlifedata.com/resource/pubmed/chemical/Ointments,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/pimecrolimus
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1742-7843
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:volume |
104
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
171-5
|
pubmed:meshHeading |
pubmed-meshheading:19143752-Administration, Cutaneous,
pubmed-meshheading:19143752-Adult,
pubmed-meshheading:19143752-Aged,
pubmed-meshheading:19143752-Anti-Inflammatory Agents,
pubmed-meshheading:19143752-Betamethasone,
pubmed-meshheading:19143752-Chemical Warfare Agents,
pubmed-meshheading:19143752-Chronic Disease,
pubmed-meshheading:19143752-Drug Administration Schedule,
pubmed-meshheading:19143752-Humans,
pubmed-meshheading:19143752-Male,
pubmed-meshheading:19143752-Middle Aged,
pubmed-meshheading:19143752-Mustard Gas,
pubmed-meshheading:19143752-Ointments,
pubmed-meshheading:19143752-Pruritus,
pubmed-meshheading:19143752-Severity of Illness Index,
pubmed-meshheading:19143752-Single-Blind Method,
pubmed-meshheading:19143752-Tacrolimus,
pubmed-meshheading:19143752-Treatment Outcome
|
pubmed:year |
2009
|
pubmed:articleTitle |
Comparison of clinical efficacy of topical pimecrolimus with betamethasone in chronic skin lesions due to sulfur mustard exposure: a randomized, investigator-blind study.
|
pubmed:affiliation |
Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Tehran, Iran. yunespanahi@yahoo.com
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial
|