Linked Life Data

19143657

Source:http://linkedlifedata.com/resource/pubmed/id/19143657

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 1
pubmed:dateCreated
2009-1-15
pubmed:abstractText
Dysfunction of the BBB (blood-brain barrier) is a major hallmark of MS (multiple sclerosis). Studies in our laboratories over the last decade have shown that increased BBB permeability is associated with decreased expression of TJ (tight junction) proteins in brain capillary endothelial cells. Results have revealed that TJ abnormalities were most common in active lesions (42% of vessels affected), but were also present in inactive lesions (23%) and in MS normal-appearing white matter (13%). Importantly, TJ abnormality was also positively associated with leakage of the serum protein fibrinogen which has recently been shown to be an activator of microglia. TJ abnormality and the resultant vascular permeability in both lesional and non-lesional white matter may impair tissue homoeostasis, which may have effects on disease progression, repair mechanisms and drug delivery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1470-8752
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-31
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis.
pubmed:affiliation
Molecular Pathology Laboratory, Institute of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, UK. s.mcquaid@qub.ac.uk
pubmed:publicationType
Journal Article, Review