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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-1-19
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pubmed:abstractText |
A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in the EBV-positive line, C666.1, and in none of five EBV-negative lines. In vitro infection of EBV-negative NPC cell lines with a recombinant EBV was followed by the down-regulation of ATM mRNA and protein, and only EBV-positive cells showed a defective DNA damage response following gamma-irradiation. Our data suggest that loss of ATM function could be an important step in the pathogenesis of NPC, and may have implications for the treatment of this disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1096-9896
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pubmed:author |
pubmed-author:ArrandJohnJ,
pubmed-author:BoseShikhaS,
pubmed-author:BuettnerMaikeM,
pubmed-author:ChukwumaMarilyn BMB,
pubmed-author:DawsonChristopherC,
pubmed-author:FungMatthewM,
pubmed-author:LimPaul V HPV,
pubmed-author:MainaEstherE,
pubmed-author:MorganSusanS,
pubmed-author:MurrayPaul GPG,
pubmed-author:SalehAmyzaA,
pubmed-author:StankovicTatjanaT,
pubmed-author:StarzcynskiJaneJ,
pubmed-author:TeoSoo HwangSH,
pubmed-author:WeiWenbinW,
pubmed-author:WoodmanCiaran B JCB,
pubmed-author:YapLee-FahLF,
pubmed-author:YoungLawrence SLS
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pubmed:issnType |
Electronic
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pubmed:volume |
217
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
345-52
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:19142888-Adenocarcinoma,
pubmed-meshheading:19142888-Case-Control Studies,
pubmed-meshheading:19142888-Cell Cycle Proteins,
pubmed-meshheading:19142888-Cell Line, Tumor,
pubmed-meshheading:19142888-DNA-Binding Proteins,
pubmed-meshheading:19142888-Down-Regulation,
pubmed-meshheading:19142888-Gene Expression Profiling,
pubmed-meshheading:19142888-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19142888-Gene Expression Regulation, Viral,
pubmed-meshheading:19142888-Herpesvirus 4, Human,
pubmed-meshheading:19142888-Humans,
pubmed-meshheading:19142888-Immunohistochemistry,
pubmed-meshheading:19142888-Nasopharyngeal Neoplasms,
pubmed-meshheading:19142888-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19142888-Protein-Serine-Threonine Kinases,
pubmed-meshheading:19142888-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19142888-Tumor Suppressor Proteins,
pubmed-meshheading:19142888-Tumor Virus Infections
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pubmed:year |
2009
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pubmed:articleTitle |
The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.
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pubmed:affiliation |
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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