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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-1-14
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pubmed:abstractText |
Adenosine is an endogenous modulator of synaptic functions in the central nervous system. The effects of adenosine are mediated by at least four adenosine receptor subtypes. Decreased density of adenosine A1 receptors, which is a major subtype adenosine receptor in the hippocampus, has been reported in vitro in Alzheimer's disease. We evaluated adenosine A1 receptor in the brain of elderly normal subjects and patients with Alzheimer's disease (n = 8 and 6, respectively), using positron emission tomography (PET) and 8- dicyclopropylmethyl-1-[(11)C]methyl-3-propylxanthine ([(11)C]MPDX).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0914-7187
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
841-7
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pubmed:meshHeading |
pubmed-meshheading:19142702-Aged,
pubmed-meshheading:19142702-Aged, 80 and over,
pubmed-meshheading:19142702-Alzheimer Disease,
pubmed-meshheading:19142702-Brain,
pubmed-meshheading:19142702-Female,
pubmed-meshheading:19142702-Humans,
pubmed-meshheading:19142702-Male,
pubmed-meshheading:19142702-Middle Aged,
pubmed-meshheading:19142702-Positron-Emission Tomography,
pubmed-meshheading:19142702-Radiopharmaceuticals,
pubmed-meshheading:19142702-Receptor, Adenosine A1,
pubmed-meshheading:19142702-Reproducibility of Results,
pubmed-meshheading:19142702-Sensitivity and Specificity,
pubmed-meshheading:19142702-Tissue Distribution,
pubmed-meshheading:19142702-Xanthines
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pubmed:year |
2008
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pubmed:articleTitle |
Adenosine A(1) receptors using 8-dicyclopropylmethyl-1-[(11)C]methyl-3-propylxanthine PET in Alzheimer's disease.
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pubmed:affiliation |
Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan. fukumitsun@yahoo.co.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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