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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-6-26
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pubmed:abstractText |
Vascular smooth-muscle cell proliferation plays an important role in atherosclerosis and restenosis. Rhein is an active component extracted from rhubarb. In this study, rhein was found to exert potent inhibitory effects against tumor necrosis factor (TNF)-alpha-induced human aortic smooth-muscle cells (HASMCs) proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0135
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-86
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pubmed:meshHeading |
pubmed-meshheading:19142017-Anthraquinones,
pubmed-meshheading:19142017-Aorta,
pubmed-meshheading:19142017-Apoptosis,
pubmed-meshheading:19142017-Apoptosis Regulatory Proteins,
pubmed-meshheading:19142017-Bongkrekic Acid,
pubmed-meshheading:19142017-Cardiovascular Agents,
pubmed-meshheading:19142017-Caspases,
pubmed-meshheading:19142017-Cell Proliferation,
pubmed-meshheading:19142017-Cells, Cultured,
pubmed-meshheading:19142017-Cysteine Proteinase Inhibitors,
pubmed-meshheading:19142017-Cytochromes c,
pubmed-meshheading:19142017-Dose-Response Relationship, Drug,
pubmed-meshheading:19142017-Humans,
pubmed-meshheading:19142017-Membrane Potential, Mitochondrial,
pubmed-meshheading:19142017-Mitochondria, Muscle,
pubmed-meshheading:19142017-Muscle, Smooth, Vascular,
pubmed-meshheading:19142017-Myocytes, Smooth Muscle,
pubmed-meshheading:19142017-Recombinant Proteins,
pubmed-meshheading:19142017-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Rhein inhibits TNF-alpha-induced human aortic smooth muscle cell proliferation via mitochondrial-dependent apoptosis.
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pubmed:affiliation |
Cardiovascular Medical Research Center and Department of Prescriptionology, University of Dongguk, Gyeongju City, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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