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pubmed-article:19141059pubmed:abstractTextThe maintenance mechanisms of peripheral tolerance by CD4(+)CD25(+) T cells before the development of sialoadenitis in secondary Sjögren's syndrome (sSS) are not well understood. The aim of the present study is to examine the effect of reduction of CD4(+)CD25(+) T cells on the development of sialoadenitis during the early life in female NZB x NZWF(1) (B/WF(1)) mice, a model for human sSS.lld:pubmed
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pubmed-article:19141059pubmed:authorpubmed-author:HasegawaKeiko...lld:pubmed
pubmed-article:19141059pubmed:authorpubmed-author:HayashiToshih...lld:pubmed
pubmed-article:19141059pubmed:authorpubmed-author:AdachiChieClld:pubmed
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pubmed-article:19141059pubmed:articleTitleSystemic treatment of anti-CD4CD25 T cell monoclonal antibody exacerbates sialoadenitis in submandibular glands during the early life in lupus-prone female NZB x NZWF mice.lld:pubmed
pubmed-article:19141059pubmed:affiliationLaboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan. hayasi@yamaguchi-u.ac.jplld:pubmed
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