Linked Life Data

19140696

Source:http://linkedlifedata.com/resource/pubmed/id/19140696

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-3-11
pubmed:abstractText
The CH(2)Cl(2)-MeOH (1:1) extract of the leaves of Hintonia standleyana and H. latiflora caused significant decrease in blood glucose levels in both normal and streptozotozin (STZ)-induced diabetic rats when compared with vehicle-treated groups (p < 0.05). These extracts were not toxic to mice according to the Lorke criteria. From the hypoglycemic extract of H. standleyana, two new 4-phenylcoumarins, namely, 6''-O-acetyl-5-O-beta-d-galactopyranosyl-7,4'-dihydroxy-4-phenylcoumarin (1) and 6''-O-acetyl-5-O-beta-d-galactopyranosyl-7,3',4'-trihydroxy-4-phenylcoumarin (2), were obtained. The analogous extract of H. latiflora yielded the new 5-O-[beta-d-xylopyranosyl-(1-->6)-beta-d-glucopyranosyl]-7,4'-dimethoxy-4-phenylcoumarin (3) along with several known compounds, including ursolic acid and desoxycordifolinic acid. Phenylcoumarins 1 and 2 showed hypoglycemic activity. HPLC profiles of the leaf extracts of both plants revealed the presence of known hypoglycemic phenylcoumarins as well as chlorogenic acid. The overall results have indicated that the leaves of H. standleyana and H. latiflora possess similar antidiabetic potential to their stem bark. Therefore, the leaves from these species could represent an alternative to the use of their stem bark, which, in turn, would contribute to the conservation of these Mexican medicinal plants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
408-13
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Hypoglycemic activity of extracts and compounds from the leaves of Hintonia standleyana and H. latiflora: potential alternatives to the use of the stem bark of these species.
pubmed:affiliation
Departamento de Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, D.F. 04510, Mexico, and Jardin Botanico, Instituto de Biologia Universidad Nacional Autonoma de Mexico, Mexico City, D.F. 04510, Mexico.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't