Source:http://linkedlifedata.com/resource/pubmed/id/19138835
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2009-3-30
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| pubmed:abstractText |
Cyclooxygenase-2 (COX-2) is involved in carcinogenesis, immune response suppression, apoptosis inhibition, angiogenesis, and tumour cell invasion and metastasis. The gene for COX-2, designated as PTGS2, carries several polymorphisms, such as -765G >C, 1195G/A in the promoter region, and 8473T >C in the 3' UTR, which have been associated with susceptibility to malignant disease. The aim of this study was to search for new mutations and polymorphisms in the COX-2 gene and to assess the relationship with breast cancer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0936-6555
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
302-5
|
| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:19138835-Breast Neoplasms,
pubmed-meshheading:19138835-Confidence Intervals,
pubmed-meshheading:19138835-Cyclooxygenase 2,
pubmed-meshheading:19138835-Female,
pubmed-meshheading:19138835-Genetic Predisposition to Disease,
pubmed-meshheading:19138835-Genetic Testing,
pubmed-meshheading:19138835-Genotype,
pubmed-meshheading:19138835-Humans,
pubmed-meshheading:19138835-Mutation,
pubmed-meshheading:19138835-Odds Ratio,
pubmed-meshheading:19138835-Polymerase Chain Reaction,
pubmed-meshheading:19138835-Polymorphism, Single Nucleotide
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer.
|
| pubmed:affiliation |
General Surgery Department, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
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| pubmed:publicationType |
Journal Article
|