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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-1-9
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pubmed:abstractText |
Fas-associated protein with death domain/mediator of receptor induced toxicity (FADD/MORT1) was first described as a transducer of death receptor signalling but was later recognized also to be important for proliferation of T cells. B-cell lymphoma 3 (Bcl-3) is a relatively little understood member of the nuclear factor (NF)-kappaB family of transcription factors. We recently found that Bcl-3 is up-regulated in T cells from mice where FADD function is blocked by a dominant negative transgene (FADD-DN). To understand the importance of this, we generated FADD-DN/bcl-3(-/-) mice. Here, we report that T cells from these mice show massive cell death and severely reduced proliferation in response to T-cell receptor (TCR) stimulation in vitro. Transgenic coexpression of Bcl-2 (FADD-DN/bcl-3(-/-)/vav-bcl-2 mice) rescued the survival but not the proliferation of T cells. FADD-DN/bcl-3(-/-) mice had normal thymocyte numbers but reduced numbers of peripheral T cells despite an increase in cycling T cells in vivo. However, activation of the classical NF-kappaB and extracellular regulated kinase (ERK) pathways and expression of interleukin (IL)-2 mRNA upon stimulation were normal in T cells from FADD-DN/bcl-3(-/-) mice. These data suggest that FADD and Bcl-3 regulate separate pathways that both contribute to survival and proliferation in mouse T cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-10452987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-10653852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-1087373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-11163182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-11292019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-11323691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-11737077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-11815739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-12089510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-12134145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-12414720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-1351092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-1378817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-15642148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-15771585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-16006518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-16030130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-16061798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-16621866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-1712491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-1971782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-2523715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-2578966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-2653378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-2783336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-2943732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-313898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-314856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-3305321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-3345338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-3416076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-3553355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-367470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-374095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-4162017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-4162018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-466667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-7216508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-7507356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-7528573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-7594547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-7690324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-789094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-8046327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-9354811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137648-9566766
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1365-2567
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
558-69
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pubmed:dateRevised |
2010-9-23
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pubmed:meshHeading |
pubmed-meshheading:19137648-Animals,
pubmed-meshheading:19137648-Antigen-Antibody Reactions,
pubmed-meshheading:19137648-Antigens, CD45,
pubmed-meshheading:19137648-Arthritis, Experimental,
pubmed-meshheading:19137648-B-Lymphocytes,
pubmed-meshheading:19137648-Biological Markers,
pubmed-meshheading:19137648-Cell Differentiation,
pubmed-meshheading:19137648-Connective Tissue Cells,
pubmed-meshheading:19137648-Female,
pubmed-meshheading:19137648-Flow Cytometry,
pubmed-meshheading:19137648-Mast Cells,
pubmed-meshheading:19137648-Peritoneal Cavity,
pubmed-meshheading:19137648-Protein Isoforms,
pubmed-meshheading:19137648-Rats,
pubmed-meshheading:19137648-Rats, Inbred Strains,
pubmed-meshheading:19137648-Serous Membrane,
pubmed-meshheading:19137648-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
Expression of a B-cell-restricted isoform of CD45 is associated with maturity in rat serosal and connective-tissue mast cells.
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pubmed:affiliation |
Institute for Medical Microbiology, Technische Universität München, Munich, Germany.
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