rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-2-12
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pubmed:abstractText |
Both environmental and genetic factors are involved in the etiology of NTDs. Inadequate folate intake and obesity are important environmental risk factors. Several folate-related genetic variants have been identified as risk factors; however, little is known about how genetic variants relate to the increased risk seen in obese women. Uncoupling Protein 2 (UCP2) is an attractive candidate to screen for NTD risk because of its possible role in obesity as well as energy metabolism, type-2 diabetes, and the regulation of reactive oxygen species. Interestingly, a previous study found that a common UCP2 compound homozygous genotype was associated with a threefold increase in NTD risk.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-10071761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-10837279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-11381268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-11440717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-12401727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-12716765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-12797456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-12915397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-14594784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-14627764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-15165610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-15220218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-15297300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-15562023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-15738989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-15870396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-16021520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-16167150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-16373902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-16463272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-16567833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-17066476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-17130180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-17199729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-17463068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-17870627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-2404255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-8116710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-8265769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-8746431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19137581-9529360
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1542-0760
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-60
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pubmed:dateRevised |
2010-9-22
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pubmed:meshHeading |
pubmed-meshheading:19137581-Case-Control Studies,
pubmed-meshheading:19137581-DNA Mutational Analysis,
pubmed-meshheading:19137581-Family,
pubmed-meshheading:19137581-Female,
pubmed-meshheading:19137581-Gene Frequency,
pubmed-meshheading:19137581-Genetic Predisposition to Disease,
pubmed-meshheading:19137581-Genetic Testing,
pubmed-meshheading:19137581-Genotype,
pubmed-meshheading:19137581-Humans,
pubmed-meshheading:19137581-Ion Channels,
pubmed-meshheading:19137581-Ireland,
pubmed-meshheading:19137581-Male,
pubmed-meshheading:19137581-Mitochondrial Proteins,
pubmed-meshheading:19137581-Neural Tube Defects,
pubmed-meshheading:19137581-Polymorphism, Single Nucleotide,
pubmed-meshheading:19137581-Risk Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Uncoupling protein 2 polymorphisms as risk factors for NTDs.
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pubmed:affiliation |
Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, 50 South Drive, Bethesda, MD 20892-8004, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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