Linked Life Data

19137362

Source:http://linkedlifedata.com/resource/pubmed/id/19137362

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pubmed-article:19137362pubmed:abstractTextWe previously demonstrated that somatostatin receptor type 5 (SSTR5) gene ablation results in alterations in insulin secretion and glucose metabolism, accompanied by morphologic alterations in the islets of Langerhans. The underlying mechanism(s) by which SSTR5 exerts its cellular functions remain(s) unknown. We hypothesized that SSTR5 mediates the inhibitory effect of somatostatin (SST) on insulin secretion and islet proliferation by regulating a specific set of pancreatic genes.lld:pubmed
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pubmed-article:19137362pubmed:articleTitleMicroarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas.lld:pubmed
pubmed-article:19137362pubmed:affiliationThe Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, TX 77030, USA.lld:pubmed
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