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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-3-16
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pubmed:abstractText |
We previously demonstrated that somatostatin receptor type 5 (SSTR5) gene ablation results in alterations in insulin secretion and glucose metabolism, accompanied by morphologic alterations in the islets of Langerhans. The underlying mechanism(s) by which SSTR5 exerts its cellular functions remain(s) unknown. We hypothesized that SSTR5 mediates the inhibitory effect of somatostatin (SST) on insulin secretion and islet proliferation by regulating a specific set of pancreatic genes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pap protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonuclease, Pancreatic,
http://linkedlifedata.com/resource/pubmed/chemical/Tde1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/angiogenin,
http://linkedlifedata.com/resource/pubmed/chemical/somatostatin receptor 5
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0364-2313
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
630-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19137362-Animals,
pubmed-meshheading:19137362-Apoptosis,
pubmed-meshheading:19137362-Cell Proliferation,
pubmed-meshheading:19137362-Down-Regulation,
pubmed-meshheading:19137362-Fluorescent Antibody Technique,
pubmed-meshheading:19137362-Gene Expression Profiling,
pubmed-meshheading:19137362-Islets of Langerhans,
pubmed-meshheading:19137362-Male,
pubmed-meshheading:19137362-Mice,
pubmed-meshheading:19137362-Mice, Knockout,
pubmed-meshheading:19137362-Neoplasm Proteins,
pubmed-meshheading:19137362-Neovascularization, Pathologic,
pubmed-meshheading:19137362-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19137362-Pancreas,
pubmed-meshheading:19137362-Proteins,
pubmed-meshheading:19137362-Receptors, Cell Surface,
pubmed-meshheading:19137362-Receptors, Somatostatin,
pubmed-meshheading:19137362-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19137362-Ribonuclease, Pancreatic,
pubmed-meshheading:19137362-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas.
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pubmed:affiliation |
The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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