Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-6
pubmed:databankReference
pubmed:abstractText
A main function of white adipose tissue is to release fatty acids from stored triacylglycerol for other tissues to use as an energy source. Whereas endocrine regulation of lipolysis has been extensively studied, autocrine and paracrine regulation is not well understood. Here we describe the role of the newly identified major adipocyte phospholipase A(2), AdPLA (encoded by Pla2g16, also called HREV107), in the regulation of lipolysis and adiposity. AdPLA-null mice have a markedly higher rate of lipolysis owing to increased cyclic AMP levels arising from the marked reduction in the amount of adipose prostaglandin E(2) that binds the Galpha(i)-coupled receptor, EP3. AdPLA-null mice have markedly reduced adipose tissue mass and triglyceride content but normal adipogenesis. They also have higher energy expenditure with increased fatty acid oxidation within adipocytes. AdPLA-deficient ob/ob mice remain hyperphagic but lean, with increased energy expenditure, yet have ectopic triglyceride storage and insulin resistance. AdPLA is a major regulator of adipocyte lipolysis and is crucial for the development of obesity.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-10715548, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-10793891, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-11013312, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-11101849, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-11278254, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-11371650, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-12518034, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-12576509, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-12576525, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-12824084, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-12837847, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-12897158, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-12923227, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-12975479, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-1317853, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-13428781, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-13671378, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-14726444, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-1475271, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-1510880, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-15888453, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-16099408, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-16303844, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-16606823, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-16675855, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-16804074, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-16936205, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-17218471, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-17313320, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-17429039, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-17962198, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-18614531, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-2539084, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-457871, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-8482433, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-8500166, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-8521497, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-8967464, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-9442016, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-9674020, http://linkedlifedata.com/resource/pubmed/commentcorrection/19136964-9674695
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1546-170X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-68
pubmed:dateRevised
2011-2-18
pubmed:meshHeading
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