Source:http://linkedlifedata.com/resource/pubmed/id/19136263
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
2009-2-3
|
pubmed:abstractText |
A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity (as low as 30 pM) versus Plasmodium falciparum and in vitro anticancer activity in the micromolar to nanomolar range versus HL-60 cell lines.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1464-3391
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:day |
1
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1325-38
|
pubmed:meshHeading |
pubmed-meshheading:19136263-Animals,
pubmed-meshheading:19136263-Antimalarials,
pubmed-meshheading:19136263-Antineoplastic Agents,
pubmed-meshheading:19136263-Artemisinins,
pubmed-meshheading:19136263-Cell Line, Tumor,
pubmed-meshheading:19136263-Dimerization,
pubmed-meshheading:19136263-HL-60 Cells,
pubmed-meshheading:19136263-Humans,
pubmed-meshheading:19136263-Plasmodium falciparum
|
pubmed:year |
2009
|
pubmed:articleTitle |
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.
|
pubmed:affiliation |
Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|