Linked Life Data

19135135

Source:http://linkedlifedata.com/resource/pubmed/id/19135135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-2-24
pubmed:abstractText
Multiple theories have been proposed for sensation seeking and vulnerability to impulse-control disorders [Zuckerman M, Kuhlman DM (2000) Personality and risk-taking: Common biosocial factors. J Pers 68:999-1029], and many of these rely on a dopamine system deficit. Available animal models reproduce only some behavioral symptoms and seem devoid of construct validity. We used lentivirus tools for over-expressing or silencing the dopamine transporter (DAT) and we evaluated the resulting behavioral profiles in terms of motivation and self-control. Wistar adult rats received stereotaxic inoculation of a lentivirus that allowed localized intra-accumbens delivery of a DAT gene enhancer/silencer, or the green fluorescent protein, GFP. These animals were studied for intolerance to delay, risk proneness and novelty seeking. As expected, controls shifted their demanding from a large reward toward a small one when the delivery of the former was increasingly delayed (or uncertain). Interestingly, in the absence of general locomotor effects, DAT over-expressing rats showed increased impulsivity (i.e. a more marked shift of demanding from the large/delayed toward the small/soon reward), and increased risk proneness (i.e. a less marked shift from the large/uncertain toward the small/sure reward), compared with controls. Rats with enhanced or silenced DAT expression did not show any significant preference for a novel environment. In summary, consistent with literature on comorbidity between attention-deficit/hyperactivity disorder and pathological gambling, we demonstrate that DAT over-expression in rats' nucleus accumbens leads to impulsive and risk prone phenotype. Thus, a reduced dopaminergic tone following altered accumbal DAT function may subserve a sensation-seeker phenotype and the vulnerability to impulse-control disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
159
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-58
pubmed:meshHeading
pubmed-meshheading:19135135-Analysis of Variance, pubmed-meshheading:19135135-Animals, pubmed-meshheading:19135135-Choice Behavior, pubmed-meshheading:19135135-Conditioning, Operant, pubmed-meshheading:19135135-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:19135135-Exploratory Behavior, pubmed-meshheading:19135135-Gene Expression Regulation, pubmed-meshheading:19135135-Green Fluorescent Proteins, pubmed-meshheading:19135135-Impulsive Behavior, pubmed-meshheading:19135135-Lentivirus, pubmed-meshheading:19135135-Male, pubmed-meshheading:19135135-Mutation, pubmed-meshheading:19135135-Nucleus Accumbens, pubmed-meshheading:19135135-Probability, pubmed-meshheading:19135135-RNA, Messenger, pubmed-meshheading:19135135-RNA, Small Interfering, pubmed-meshheading:19135135-Rats, pubmed-meshheading:19135135-Rats, Wistar, pubmed-meshheading:19135135-Reward, pubmed-meshheading:19135135-Risk-Taking, pubmed-meshheading:19135135-Statistics as Topic
pubmed:year
2009
pubmed:articleTitle
Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens.
pubmed:affiliation
Behavioral Neuroscience Section, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, viale Regina Elena 299, I-00161, Roma, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't