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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-2-3
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pubmed:abstractText |
Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. BCL2/IGH rearrangements were found in three cases; HLA-DRB1*07 in all. Bone marrow (BM) trephines showed a moderate lymphoid infiltrate with intrasinusoidal distribution resembling a splenic marginal-zone lymphoma. Splenic white pulp revealed an enlargement of the marginal-zone area; red pulp was infiltrated by the same lymphocytes engulfing the sinuses. Splenic and BM B-lymphocytes were CD79a(+)/CD20(+)/IgM(+)/IgD(+)/bcl-2(+)/CD27(+)/DBA.44(-)/CD31(-) and polyclonal by immunophenotype/polymerase chain reaction. PPBL features an expansion of splenic marginal-zone B-lymphocytes, which infiltrate BM sinusoids and circulate in the blood with no evidence of clonality, even in cases with progressive splenomegaly.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1365-2141
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pubmed:author |
pubmed-author:AmendolaAngelaA,
pubmed-author:ArmientoDanieleD,
pubmed-author:CampidelliCristinaC,
pubmed-author:De ProprisMaria SMS,
pubmed-author:Del GiudiceIlariaI,
pubmed-author:ElenaSabattiniS,
pubmed-author:FoàRobinR,
pubmed-author:GesuitiPaolaP,
pubmed-author:GuariniAnnaA,
pubmed-author:ManciniFrancescaF,
pubmed-author:MauroFrancesca RFR,
pubmed-author:PerroneMaria PMP,
pubmed-author:PileriStefano ASA,
pubmed-author:QuattrocchiLuisaL,
pubmed-author:RossiMauraM,
pubmed-author:StarzaIrene DellaID,
pubmed-author:TafuriAgostinoA
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pubmed:issnType |
Electronic
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
726-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19133977-Adolescent,
pubmed-meshheading:19133977-Adult,
pubmed-meshheading:19133977-B-Lymphocytes,
pubmed-meshheading:19133977-Bone Marrow,
pubmed-meshheading:19133977-Female,
pubmed-meshheading:19133977-Follow-Up Studies,
pubmed-meshheading:19133977-Gene Rearrangement,
pubmed-meshheading:19133977-HLA-DR Antigens,
pubmed-meshheading:19133977-HLA-DRB1 Chains,
pubmed-meshheading:19133977-Humans,
pubmed-meshheading:19133977-Immunoglobulin Heavy Chains,
pubmed-meshheading:19133977-Immunophenotyping,
pubmed-meshheading:19133977-Lymphocyte Count,
pubmed-meshheading:19133977-Lymphocytosis,
pubmed-meshheading:19133977-Male,
pubmed-meshheading:19133977-Polymerase Chain Reaction,
pubmed-meshheading:19133977-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:19133977-Smoking,
pubmed-meshheading:19133977-Spleen,
pubmed-meshheading:19133977-Splenectomy,
pubmed-meshheading:19133977-Splenomegaly,
pubmed-meshheading:19133977-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Histopathological and molecular features of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly.
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pubmed:affiliation |
Department of Cellular Biotechnologies and Haematology, Division of Haematology, Sapienza University, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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