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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-30
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pubmed:abstractText |
Eczema is a common chronic inflammatory skin disorder which shows strong genetic predisposition. To identify new potential molecular determinants of the disease pathogenesis, we performed a gene expression study in an eczema mouse model. This analysis identified a marked down regulation of the cornulin gene (CRNN), a member of the epidermal differentiation complex, in the eczema-like skin. We then investigated CRNN as an eczema candidate gene and studied its polymorphism and the expression in the skin of eczema patients.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Dermatophagoides,
http://linkedlifedata.com/resource/pubmed/chemical/Arthropod Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CRNN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Dermatophagoides pteronyssinus...,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1398-9995
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pubmed:author |
pubmed-author:BjörksténBB,
pubmed-author:BradleyMM,
pubmed-author:D'AmateCC,
pubmed-author:EkelundEE,
pubmed-author:GrayA HAH,
pubmed-author:HOCKC WCW,
pubmed-author:HuangC-HCH,
pubmed-author:KockumII,
pubmed-author:KuoI-CIC,
pubmed-author:LeeS PSP,
pubmed-author:LiedénAA,
pubmed-author:MallbrisLL,
pubmed-author:NordensköldMM,
pubmed-author:NordenskjöldMM,
pubmed-author:PalmerC N ACN,
pubmed-author:StåhleMM,
pubmed-author:TOPPD CDC,
pubmed-author:WahlgrenC-FCF
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pubmed:issnType |
Electronic
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
304-11
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19133922-Adult,
pubmed-meshheading:19133922-Allergens,
pubmed-meshheading:19133922-Animals,
pubmed-meshheading:19133922-Antigens, Dermatophagoides,
pubmed-meshheading:19133922-Arthropod Proteins,
pubmed-meshheading:19133922-Cytokines,
pubmed-meshheading:19133922-Dermatitis, Atopic,
pubmed-meshheading:19133922-Down-Regulation,
pubmed-meshheading:19133922-Epidermis,
pubmed-meshheading:19133922-Female,
pubmed-meshheading:19133922-Gene Expression,
pubmed-meshheading:19133922-Gene Expression Regulation,
pubmed-meshheading:19133922-Genetic Markers,
pubmed-meshheading:19133922-Genetic Predisposition to Disease,
pubmed-meshheading:19133922-Genotype,
pubmed-meshheading:19133922-Haplotypes,
pubmed-meshheading:19133922-Humans,
pubmed-meshheading:19133922-Immunoglobulin E,
pubmed-meshheading:19133922-Male,
pubmed-meshheading:19133922-Membrane Proteins,
pubmed-meshheading:19133922-Mice,
pubmed-meshheading:19133922-Mice, Inbred BALB C,
pubmed-meshheading:19133922-Middle Aged,
pubmed-meshheading:19133922-Neoplasm Proteins,
pubmed-meshheading:19133922-Polymorphism, Single Nucleotide,
pubmed-meshheading:19133922-Psoriasis
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pubmed:year |
2009
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pubmed:articleTitle |
Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema.
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pubmed:affiliation |
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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