Linked Life Data

19132878

Source:http://linkedlifedata.com/resource/pubmed/id/19132878

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-12-1
pubmed:abstractText
Despite zinc ions being redox inert in biologic systems, zinc-finger structures act as redox-sensitive molecular switches controlling several crucial cellular processes. Oxidative or nitrosative stress, via modification of zinc finger cysteine thiols, leads to a release of Zn(2+) from these structures, causing not only a loss of zinc-finger function but also an increase of cytoplasmic or nuclear free Zn(2+) that may, in turn, stimulate and interfere with cellular signaling cascades. A signaling cascade stimulated by exposure of cells to zinc ions or to stressful stimuli that are reported to cause an intracellular release of zinc ions involves phosphoinositide 3'-kinases and the Ser/Thr protein kinase Akt, resulting in an inactivation of transcriptional regulators of the FoxO family. Possible modes of action of zinc ions to stimulate this signaling cascade and consequences of stimulation are discussed. Moreover, we present an overview on human diseases or disorders characterized by an intracellular Zn(2+) dyshomeostasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1557-7716
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1015-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Zinc fingers as biologic redox switches?
pubmed:affiliation
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany. kroencke@uni-duesseldorf.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't