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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-5
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pubmed:abstractText |
Simocyclinone D-8 (SD8), a semi-synthetic compound derived from yeast, has been shown to decrease the proliferation of MCF-7 breast cancer cells. It has been shown to be a potent bacterial DNA gyrase inhibitor, a homologue of human topoisomerase II (hTopoII). We tested SD8 activity alone and in combination with cisplatin against malignant mesothelioma (MM) and non-small cell cancer (NSCLC) cell lines.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1573-0646
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19132295-Apoptosis,
pubmed-meshheading:19132295-Biocatalysis,
pubmed-meshheading:19132295-Cell Line, Tumor,
pubmed-meshheading:19132295-Cell Proliferation,
pubmed-meshheading:19132295-Coumarins,
pubmed-meshheading:19132295-DNA Topoisomerases, Type II,
pubmed-meshheading:19132295-Drug Screening Assays, Antitumor,
pubmed-meshheading:19132295-Enzyme Inhibitors,
pubmed-meshheading:19132295-Glycosides,
pubmed-meshheading:19132295-Humans,
pubmed-meshheading:19132295-Topoisomerase II Inhibitors
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pubmed:year |
2010
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pubmed:articleTitle |
Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II.
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pubmed:affiliation |
Division of Hematology-Oncology-Transplant, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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