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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-3-11
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pubmed:abstractText |
The activation state of CD4(+) T cells plays a crucial role in the establishment of a productive human immunodeficiency virus infection. Here, we show that T cells stimulated for 1 day demonstrated delayed kinetics of viral reverse transcription and integration compared to cells stimulated for 2 days prior to infection. As a result, the efficiency of reverse transcription and integration inhibitors differs in these differentially stimulated cells. These studies increase our understanding of how T cells support viral replication and provide insight regarding the efficiency of antiretroviral therapy in lymphoid compartments.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-10074203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-10359577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-10400748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-10601505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-11672548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-12163571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-12202041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-12368337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-12551992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-1371173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-14722271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-15016842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-15117452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-15162441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-15247437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-15681422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-15818415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-16254353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-17229711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-17545577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-17591678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-17713476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-17928354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-2184033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-2331748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-7507180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-7529174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-7572399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-7629519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-7707524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-8096068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-8592986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-9525642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-9670934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-9754886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19129455-9841925
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1098-5514
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3374-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents.
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pubmed:affiliation |
David Geffen School of Medicine at UCLA, Department of Medicine, Division of Hematology/Oncology, Los Angeles, California 90095, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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