Source:http://linkedlifedata.com/resource/pubmed/id/19129082
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2009-3-6
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pubmed:abstractText |
Vitiligo is a common skin disorder characterized by patterned depigmentation, because of a decrease of melanin pigment resulting from apparent melanocyte loss. The aim of this study was to investigate interleukin 4 (IL4), Angiotensin Converting Enzyme (ACE), C-C Chemocine Receptor 5 (CCR5), Cytotoxic T Lymphocyte-associated Antigen Receptor 4 (CTLA4) and Interleukin 1 Receptor Antagonist (IL1-RN) gene polymorphisms in 48 Turkish vitiligo patients and 50 healthy controls. Polymorphisms for the genes ACE insertion(I)/deletion(D), CCR5 (Delta32), IL1-RN (VNTR in intron 2) were detected by PCR methods. IL4 (-590) and CTLA4 (+49) gene polymorphisms were typed using PCR-RFLP methods. No significant differences in either the genotype distribution or allele frequencies of IL4, CCR5 and ACE gene polymorphisms were observed. GG genotype and G allele in CTLA4 genes were found to be significantly higher in vitiligo patients compared to the controls. (0.002, 0.000). CTLA4 (AA) and IL1-RN (1/5) genotypes and 5 allele frequency in the IL1-RN gene were found to be significantly lower in vitiligo patients compared to healthy controls (p: 0.014, 0.015, 0.016, respectively). As a conclusion, CTLA4 and IL1-RN genes might play roles in the genetic etiology of vitiligo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5
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pubmed:status |
MEDLINE
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pubmed:issn |
1167-1122
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19129082-Alleles,
pubmed-meshheading:19129082-Antigens, CD,
pubmed-meshheading:19129082-CTLA-4 Antigen,
pubmed-meshheading:19129082-Case-Control Studies,
pubmed-meshheading:19129082-Chi-Square Distribution,
pubmed-meshheading:19129082-Electrophoresis, Agar Gel,
pubmed-meshheading:19129082-Genotype,
pubmed-meshheading:19129082-Humans,
pubmed-meshheading:19129082-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:19129082-Interleukin-4,
pubmed-meshheading:19129082-Introns,
pubmed-meshheading:19129082-Peptidyl-Dipeptidase A,
pubmed-meshheading:19129082-Polymerase Chain Reaction,
pubmed-meshheading:19129082-Polymorphism, Genetic,
pubmed-meshheading:19129082-Receptors, CCR5,
pubmed-meshheading:19129082-Turkey,
pubmed-meshheading:19129082-Vitiligo
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pubmed:articleTitle |
Association between IL4 (-590), ACE (I)/(D), CCR5 (Delta32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo.
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pubmed:affiliation |
Gaziantep University Faculty of Medicine, Department of Medical Biology, 27060 Gaziantep, Turkey.
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pubmed:publicationType |
Journal Article
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