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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-3-2
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pubmed:abstractText |
The Wnt/beta-catenin signaling is important for controlling self-renewal of hematopoietic stem cells and its constitutive activation has recently been documented in a significant proportion of acute myeloid leukemia (AML) cases. Topoisomerase IIalpha (Topo IIalpha) is a marker of cell proliferation and a crucial target for anthracycline cytotoxicity, the mainstay of management employed in AML. We retrospectively investigated the prognostic roles of beta-catenin and topo IIalpha in a cohort of 59 patients with newly diagnosed AML by immunohistochemistry. Aberrant beta-catenin expression was demonstrated in 13 patients (22%), and it was more likely to occur in those with unfavorable karyotypes. Advanced age and poor performance status adversely influenced the achievement of complete remission, while neither aberrant beta-catenin expression nor enhanced topo IIalpha activity did. On multivariate survival analysis, four factors independently predicted a shortened overall survival: aberrant beta-catenin expression, high topo IIalpha activity, poor-risk cytogenetics, and presence of at least one comorbidity factor. Our results suggest that both beta-catenin and topo IIalpha independently predicted an adverse prognosis and might serve as new markers for risk stratification in AML patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytarabine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type II,
http://linkedlifedata.com/resource/pubmed/chemical/DNA topoisomerase II alpha,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1096-8652
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pubmed:author |
pubmed-author:ChenChih-ChengCC,
pubmed-author:GauJyh-PyngJP,
pubmed-author:LanChiehC,
pubmed-author:LeeKuan-DerKD,
pubmed-author:LinJen-TsunJT,
pubmed-author:LiuJacqueline MingJM,
pubmed-author:LoWan-HsiaWH,
pubmed-author:LuChang-HsienCH,
pubmed-author:YangChing-FenCF,
pubmed-author:YouJie-YuJY,
pubmed-author:YuYuan-BinYB
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pubmed:issnType |
Electronic
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-92
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19127593-Adult,
pubmed-meshheading:19127593-Aged,
pubmed-meshheading:19127593-Aged, 80 and over,
pubmed-meshheading:19127593-Antigens, Neoplasm,
pubmed-meshheading:19127593-Antimetabolites, Antineoplastic,
pubmed-meshheading:19127593-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19127593-Cohort Studies,
pubmed-meshheading:19127593-Comorbidity,
pubmed-meshheading:19127593-Cytarabine,
pubmed-meshheading:19127593-DNA Topoisomerases, Type II,
pubmed-meshheading:19127593-DNA-Binding Proteins,
pubmed-meshheading:19127593-Female,
pubmed-meshheading:19127593-Humans,
pubmed-meshheading:19127593-Karyotyping,
pubmed-meshheading:19127593-Leukemia, Myeloid, Acute,
pubmed-meshheading:19127593-Male,
pubmed-meshheading:19127593-Middle Aged,
pubmed-meshheading:19127593-Neoplasm Proteins,
pubmed-meshheading:19127593-Prognosis,
pubmed-meshheading:19127593-Retrospective Studies,
pubmed-meshheading:19127593-Risk Factors,
pubmed-meshheading:19127593-Survival Analysis,
pubmed-meshheading:19127593-Tumor Markers, Biological,
pubmed-meshheading:19127593-Wnt Proteins,
pubmed-meshheading:19127593-beta Catenin
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pubmed:year |
2009
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pubmed:articleTitle |
Prognostic significance of beta-catenin and topoisomerase IIalpha in de novo acute myeloid leukemia.
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pubmed:affiliation |
Division of Hematology Oncology, Department of Medicine, Chang Gung Memorial Hospital-Chiayi, Chiayi, Taiwan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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