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pubmed:abstractText |
Glyco oligonucleotide conjugates, each exhibiting two mannose and two galactose residues, were efficiently synthesized by two successive 1,3-dipolar cycloadditions (click chemistry). Two phosphoramidite derivatives were used: one bearing a bromoalkyl group as a precursor to azide functionalization and another bearing a propargyl group. After a first cycloaddition with a mannosyl-azide derivative, the bromine atoms were substituted with NaN(3) and a second click reaction was performed with a 1'-O-propargyl galactose, affording the heteroglyco oligonucleotide conjugate.
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pubmed:affiliation |
Institut des Biomolecules Max Mousseron, UMR 5247 CNRS, Universite Montpellier 1, Place Eugene Bataillon, CC1704, 34095 Montpellier Cedex 5, France.
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