Source:http://linkedlifedata.com/resource/pubmed/id/19121870
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2009-3-6
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pubmed:abstractText |
RIP2/RICK/CARDIAK is a member of the receptor interacting protein kinase (RIP) family. RIP2 promotes NF-kappaB activation as well as activation of the MAPKs JNK, ERK1/2 and p38 MAPK, thereby playing an emergent role in the innate immune response and NOD signaling. Moreover, RIP2 has been shown to interact with the CARD of caspase-1 and to induce IL-1beta maturation as well as in the induction of CD95-mediated programmed cell death by enhancing caspase-8 activity. Here, we report the identification and characterization of a novel alternative mRNA splice variant of RIP2, encoding a protein designated RIP2-beta, comprised of only a portion of the N-terminal kinase domain and lacking the intermediate region and C-terminal CARD. As revealed by gene transfer experiments, these structural changes in RIP2-beta are associated with a loss of activation with respect to NF-kappaB and MAPK activation, IL-1beta secretion, and caspase-8-mediated apoptosis. In conclusion, alternative mRNA splicing may be involved in the regulation of RIP2 actions, underlying the complexity of RIP2-dependent pathways regulating stress signaling and apoptosis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/RIPK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor-Interacting Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1872-9142
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1163-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19121870-Alternative Splicing,
pubmed-meshheading:19121870-Amino Acid Sequence,
pubmed-meshheading:19121870-Apoptosis,
pubmed-meshheading:19121870-Base Sequence,
pubmed-meshheading:19121870-Caspase 8,
pubmed-meshheading:19121870-Cell Line,
pubmed-meshheading:19121870-Humans,
pubmed-meshheading:19121870-Interleukin-1beta,
pubmed-meshheading:19121870-Mitogen-Activated Protein Kinases,
pubmed-meshheading:19121870-Molecular Sequence Data,
pubmed-meshheading:19121870-NF-kappa B,
pubmed-meshheading:19121870-RNA, Messenger,
pubmed-meshheading:19121870-Receptor-Interacting Protein Serine-Threonine Kinase 2,
pubmed-meshheading:19121870-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
RIP2-beta: a novel alternative mRNA splice variant of the receptor interacting protein kinase RIP2.
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pubmed:affiliation |
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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