| pubmed-article:19121610 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C0520510 | lld:lifeskim |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C0243003 | lld:lifeskim |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C1721059 | lld:lifeskim |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C0243067 | lld:lifeskim |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C0443220 | lld:lifeskim |
| pubmed-article:19121610 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:19121610 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19121610 | pubmed:dateCreated | 2009-5-5 | lld:pubmed |
| pubmed-article:19121610 | pubmed:abstractText | The easy clinical handling and applicability of biomaterials has become a focus of materials research due to rapidly increasing time and cost pressures in the public health sector. The present study assesses the in vitro and in vivo performance of a flexible, mouldable, cottonwool-like nanocomposite based on poly(lactide-co-glycolide) and amorphous tricalcium phosphate nanoparticles (PLGA/TCP 60:40). Immersion in simulated body fluid showed exceptional in vitro bioactivity for TCP-containing fibres (mass gain: 18%, 2 days, HAp deposition). Bone regeneration was quantitatively investigated by creating four circular non-critical-size calvarial defects in New Zealand White rabbits. The defects were filled with the easy applicable cottonwool-like PLGA/TCP fibres or PLGA alone. Porous bovine-derived mineral (Bio-Oss) was used as a positive control and cavities left empty served as a negative control. The area fraction of newly formed bone (4 weeks implantation) was significantly increased for TCP-containing fibres compared to pure PLGA (histological and micro-computed tomographic analysis). A spongiosa-like structure of the newly formed bone tissue was observed for PLGA/TCP nanocomposites, whereas Bio-Oss-treated defects afforded a solid cortical bone. | lld:pubmed |
| pubmed-article:19121610 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19121610 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19121610 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19121610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19121610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19121610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19121610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19121610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19121610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19121610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19121610 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19121610 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19121610 | pubmed:issn | 1878-7568 | lld:pubmed |
| pubmed-article:19121610 | pubmed:author | pubmed-author:SchmidlinPatr... | lld:pubmed |
| pubmed-article:19121610 | pubmed:author | pubmed-author:EhrbarMartinM | lld:pubmed |
| pubmed-article:19121610 | pubmed:author | pubmed-author:StarkWendelin... | lld:pubmed |
| pubmed-article:19121610 | pubmed:author | pubmed-author:WeberFranzF | lld:pubmed |
| pubmed-article:19121610 | pubmed:author | pubmed-author:LoherStefanS | lld:pubmed |
| pubmed-article:19121610 | pubmed:author | pubmed-author:BrunnerTobias... | lld:pubmed |
| pubmed-article:19121610 | pubmed:author | pubmed-author:SchneiderOliv... | lld:pubmed |
| pubmed-article:19121610 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19121610 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:19121610 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19121610 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19121610 | pubmed:pagination | 1775-84 | lld:pubmed |
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| pubmed-article:19121610 | pubmed:meshHeading | pubmed-meshheading:19121610... | lld:pubmed |
| pubmed-article:19121610 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19121610 | pubmed:articleTitle | In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects. | lld:pubmed |
| pubmed-article:19121610 | pubmed:affiliation | Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, 8093 Zurich, Switzerland. | lld:pubmed |
| pubmed-article:19121610 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19121610 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19121610 | lld:pubmed |
